Antenatal magnesium sulphate for neuroprotection- Recommendations & gaps in knowledge
The main mechanism of neuroprotection action of magnesium is by acting as a cerebral vasodilator and blocking calcium mediated cell injury. Some studies suggest that magnesium sulphate decreases the production of free radicals and pro-inflammatory cytokines after ischemic insult. A study showed that neonates whose mothers received antenatal magnesium sulphate had higher cord levels of brain derived neurotrophic factor (BDNF), which has been shown to be protective against hypoxic brain injury in vivo.
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