Research Paper

Helicobacter Pylori Infection in Amniotic Fluid May Cause Hyperemesis Gravidarum

  Abstract :

Objectives: Limited data are avaible from recent trials involving pregnant women to guide the diagnosis of Helicobacter pylori infection. There is no data about presence ofH. pylori in the amniotic fluid as well. Furthermore, relation between amniotic fluid H. pylori and hyperemesis gravidarum (HG) has not been characterized yet.Materials and Methods: Pregnant women undergoing amniocentesis were enrolled in the study. Presence of H. pylori in amniotic fluid was assessed by stool antigen test. A perinatalogist independently performed amniocentesis. Obtained amniotic fluid was sent to the laboratory to assess H. pylori infection by stool H. pylori antigen assay. We determined the rate of H. pylori in amniotic fluid and assessed relations between H. pylori infection and pregnancy outcome including HG.Results: Between May 2017 - September 2017, we enrolled 48 pregnant women who underwent amniocentesis to detect possible fetal malformations. Among them, 28 (58.3%) were found to have positive for H. pylori in the amniotic fluid. The rate of HG was significantly higher (71.4%) in patients who tested positive for H. pylori in amniocentesis than H. pylori negative group (20%), (p

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