Original Research Paper

A study of correlation of serum anti -Mullerian hormone (AMH) and insulin resistance (IR) in PCOS women

  Abstract :

Introduction : Polycystic ovary syndrome(PCOS) is a prevalent disease mostly affecting the women of reproductive age. It may be associated with metabolic disorders such as insulin resistance, diabetes mellitus, and cardiovascular disorders. Anti Mullerian hormone levels have been found higher in PCOS women as compared to women without PCOS. This can be due to hyperinsulinemia and hyperandrogenism commonly seen in these women. Aim and Objective: The present study was designed to evaluate the association between serum AMH and insulin resistance(IR) in PCOS women with and without IR. Method: It was a Cross-sectional study, including 90 women, selected and divided in 3 groups: Group-A : 36 women with PCOS and IR, Group-B : 36 women with PCOS and without AIR, Group-C : 18 control without PCOS. Results : We found AMH levels to be significantly higher in women with PCOS as compared with women without PCOS. Serum AMH levels were higher in women with PCOS and IR, thus showing that PCOS and IR play an important role in elevating the levels of this hormone. Conclusion : AMH levels are significantly higher in patients with PCOS, particularly associated with IR suggesting a correlation between AMH, PCOS and IR .Serum AMH plays a role in prediction of insulin resistance in PCOS

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